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Many individuals battle to maintain their weight in verify as they grow old. Now new analysis at Karolinska Institutet has uncovered why that’s: Lipid turnover within the fats tissue decreases throughout ageing and makes it simpler to realize weight, even when we don’t eat extra or train lower than earlier than. The examine is printed within the journal Nature Drugs.

The scientists studied the fats cells in 54 women and men over a median interval of 13 years. In that point, all topics, no matter whether or not they gained or misplaced weight, confirmed decreases in lipid turnover within the fats tissue, that’s the price at which lipid (or fats) within the fats cells is eliminated and saved. Those that didn’t compensate for that by consuming fewer energy gained weight by a median of 20 %, in keeping with the examine which was finished in collaboration with researchers at Uppsala College in Sweden and College of Lyon in France.

Kirsty Spalding, senior researcher on the Division of Cell and Molecular Biology. Credit score: Stefan Zimmerman

Lowering lipid turnover within the fats tissue

The researchers additionally examined lipid turnover in 41 ladies who underwent bariatric surgical procedure and the way the lipid turnover price affected their skill to maintain the burden off 4 to seven years after surgical procedure. The consequence confirmed that solely those that had a low price earlier than the surgical procedure managed to extend their lipid turnover and keep their weight loss. The researchers imagine these folks could have had extra room to extend their lipid turnover than those that already had a high-level pre-surgery.

“The outcomes point out for the primary time that processes in our fats tissue regulate adjustments in physique weight throughout ageing in a means that’s unbiased of different components,” says Peter Arner, professor on the Division of Drugs in Huddinge at Karolinska Institutet and one of many examine’s important authors. “This might open up new methods to deal with weight problems.”

Extra train and fewer energy

Prior research have proven that one solution to pace up the lipid turnover within the fats tissue is to train extra. This new analysis helps that notion and additional signifies that the long-term results of weight-loss surgical procedure would enhance if mixed with elevated bodily exercise.

“Weight problems and obesity-related ailments have change into a worldwide drawback,” says Kirsty Spalding, senior researcher on the Division of Cell and Molecular Biology at Karolinska Institutet and one other of the examine’s important authors. “Understanding lipid dynamics and what regulates the scale of the fats mass in people has by no means been extra related.”

The examine was financed by grants from the Stockholm County Council, the Swedish Analysis Council, the Strategic Analysis Program for Diabetes at Karolinska Institutet, the Novo Nordisk Basis, the Swedish Diabetes Basis, Karolinska Institutet-Astra Zeneca Built-in Cardiometabolic Middle, the Vallee Basis, the Swedish Society of Drugs, the Erling-Persson Household basis and IXXI.


Reference: “Adipose lipid turnover and long run adjustments in physique weight” by Peter Arner, Samuel Bernard, Lena Appelsved, Keng-Yeh Fu, Daniel Andersson, Mehran Salehpour, Anders Thorell, Mikael Rydén, Kirsty Spalding, September 9, 2019, Nature Drugs.
DOI: 10.1038/s41591-019-0565-5